When DNA breaks, cells must repair it accurately to prevent harmful mutations. Researchers have discovered that during a key ...

The DNA inside our cells is constantly being damaged, and one of the worst kinds of damage is a double-strand break—when both ...

*仅供医学专业人士阅读参考最近这一个月，围绕DNA修复的重磅研究非常多。10月中旬，同济大学团队发表在《科学》杂志上的论文显示，裸鼹鼠在进化过程中，替换了cGAS蛋白的四个氨基酸，将其从抑制DNA修复转变为增强DNA修复[1]。这也保证裸鼹鼠健康长寿 ...

本研究系统揭示了DNA双链断裂修复后的一个被长期忽视的层面：染色质结构与基因功能的不可逆改变。这种结构性与功能性损伤可稳定地传递给子代细胞，形成一种可遗传的基因表达缺陷，被作者定义为“染色质疲劳（chromatin ...

After two decades in the making, scientists have cracked the code on a drug that can repair DNA, setting the scene for a new ...

A breakthrough live-cell sensor makes DNA repair visible as it happens, unlocking new possibilities in biology and medicine.

Cedars-Sinai scientists have created a new experimental drug called TY1 that helps the body repair damaged DNA and restore ...

Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a double-strand break involves the severing of both strands of the DNA double ...

Scientists have created a live-cell DNA sensor that reveals how damage appears and disappears inside living cells, capturing ...

New live-cell DNA damage sensor lets scientists watch repair unfold in real time, potentially opening doors for cancer and aging research.

The sensor lets researchers watch DNA damage and repair as it happens in living cells and organisms, making studies possible.

Learn about the innovative fluorescent sensor technology that visualizes DNA damage and repair in real time, enhancing medical research.